Curriculum vitae of Michael A. Ferenczi

Present address:Lee Kong Chian School of Medicine, 59 Nanyang Drive, Experimental Medicine Building, Room 03-P10, Singapore 636921; e-mail: m.ferenczi**
Web site:
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B.Sc. 19741st Class Honours, Physiology, University College London.
Ph.D. 1978Physiology, University College London. Supervisor: R.M. Simmons, F.R.S.; A.G. Weeds, F.R.S., D. R. Trentham, F.R.S.
ESME 2012 Association for Medical Education in Europe (AMEE): Certificate in Medical Education - Essential Skills in Medical Education (ESME)


August 2017Appointed Vice-Dean, Faculty Affairs, in LKCMedicine
August 2016Elected Chair of NTU Senate and Senate Steering Committee
Since August 2012Professor of Medical Sciences, LKCMedicine, Nanyang Technological University, Singapore
Since August 2012Assistant Dean, Years 1 & 2, LKCMedicine, NTU, Singapore
Since August 2012; renewed July 2015Visiting Professor, NHLI, Imperial College London
August 2007-2012Head of Molecular Medicine Section in NHLI, Faculty of Medicine
March 2001-2012Professor of Physiological Sciences, Imperial College London.
1983 - 2001MRC Scientific Staff, (Senior Staff since 1990), NIMR, London, U.K.
1982 - 1983Research Assistant, University of Pennsylvania, Philadelphia, USA.
1980 - 1982Fellow of the Muscular Dystrophy Association, University of Pennsylvania, Philadelphia.
1977 - 1980Beit Memorial Fellow, University College London.


April 2015. Nanyang Education Award (School). NTU Newsletter April 2015 )
July 2012. Elected Honorary Member of the British Biophysical Society. (

Current Administrative Responsibilities:

February 2016 - 31 July 2018 Member of the NTU Teaching Council
December 2015 - 31 July 2017Elected faculty representative on the School Management Board
September 2014 - August 2015 URECA school coordinator for LKCMedicine
July 2013 Editor, European Biophysics Journal
May 2013 Member of the NTU Research Council (NTURC) Sub-Committee for the Discipline Cluster: EP3 Biomedical & Life Sciences
December 2012 Member of NTU Library Committee
December 2012 Member of Editorial board for the LKCMedicine bi-monthly newsletter
December 2012 Member of the Health and Safety Committee for LKCMedicine
August 2012 Assistant Dean, Years 1 & 2, LKCMedicine, NTU, Singapore

Previous Administrative Responsibilities:

October 2014-2016 Elected Deputy Chairman of NTU Senate
October 2014-2016 Elected member of NTU Senate Steering Committee
November 2013 and October 2014 Elected member of NTU Senate
March 2013-August 2014 Member of NTU Senate Committee on Campus Life
December 2011European Synchrotron Radiation Facility (ESRF) SAC member to 2012
August 2007-2012Head of Molecular Medicine Section in the National Heart and Lung Institute, Faculty of Medicine (Imperial web page)
November 2007-2012Head of Year 4 (B.Sc. Year) in Undergraduate Medicine
2009-2012Committee Member, British Biophysical Society
August 2009-2012Vice-President and Treasurer, European Biophysical Societies Association (EBSA)
October 2007-2012Member of Review Committee (SC) for the European Synchrotron Radiation Facility (ESRF)
2005-2009Member of MRC College of Experts
2007-2009President, European Biophysical Societies Association (EBSA)
2002-2009Editor, Journal of Physiology
1984-2007Committee Member, British Biophysical Society
2002-2007Theme leader for Year 1/ Year 2 Undergraduate Medicine Course: 'Molecules Cells and Disease'
2006-2007Head of Biological Nanoscience Section in the National Heart and Lung Institute, Faculty of Medicine
2005-2006Head of Biological Nanoscience Section in the Biomedical Sciences Division, Faculty of Natural Sciences, Imperial College London.
2005-2007Vice-President, European Biophysical Societies Association (EBSA)
14-18 July 2007Chairman of the Organising Committee, 2007 European Biophysics Congress, Imperial College London.
January 2005Independent expert. Sixth Framework Programme of the European Community. Research Training Networks.
April 2002Membre du comité d'évaluation CNRS de l'UPR 4301 - Centre de Biophysique Moléculaire in Orleans
1997-2003EBSA Honorary Treasurer
1997-2005Member of the Advisory Board, Medical Research Council
1995Member of the Biological Selection Panel, CCLRC Daresbury Laboratory and Member of the Beam Allocation Panel
1995Member of the CCP13 Committee (EPSRC Collaborative Computing Project 13)

Membership of Learned Societies:

The Physiological Society
British Biophysical Society
Biophysical Society

Ph.D. examiner:

University of York (2x)University of Keele
Free University of AmsterdamUniversity of Montpellier (3x)
University of CambridgeImperial College London (x2)
University of Leeds 

Supervisor to the following Ph.D. students:

Dr. C.I. Spencer (Chemomechanical coupling in skeletal muscle, 1988),
Dr. S.K.A. Woodward (The role of adenosine 5'-diphosphate in muscle contraction, 1990),
Dr. J.R. Patel (The kinetics of calcium-induced calcium release in the heart, 1992),
Dr. H. Thirlwell (Kinetics of mechano-chemical coupling in muscle fibres, 1995),
Dr. R.I.S. Burns (Kinetic investigation of the mechanism underlying muscle contraction in myofibrils using TIRF microscopy, 1998),
Dr. V. Siththanandan (Strain dependency of actomyosin kinetics in isometric muscle fibres, 2005),
Dr. C. Batters (Single molecule mechanical studies of myosin-I, 2005, jointly with Justin Molloy),
Dr. Alison Stubbings (In vitro physiological properties of diaphragm muscle in chronic obstructive pulmonary disease, 2007, jointly with Prof. Michael Polkey),
Dr. Delisa Ibanez Garcia (Fluorescence lifetime imaging applied to the study of muscle contraction, 2007, jointly with Professor Paul French),
Dr. Catherine Mansfield (The actomyosin ATPase response to stretch in cardiac muscle, 2012, jointly with Dr. T. West),
Dr. Christopher Töpfer (The role of myosin regulatory light chain phosphorylation in cardiac health and disease, 2015, jointly with Dr. Jim Sellers, NIH),
Dr. Sara Abou Al-Saud (Investigation of phenotypic rescue of Mybpc3 deficient mouse, 2015, jointly with Professors Ralph Knöll and Steven Marston, NHLI, Imperial College London).
Ms. Changaramvally Madathummal Mufeeda (jointly with Dr. Sara Sandin, School of Biological Sciences, NTU), from August 2014.

Current grant support:

Singapore Ministry of Education Tier 2, MOE2016-T2-1-106; "Physiology & Anatomy of Heart Failure Progression: Role of RLC Phosphorylation", 03-Jan-2017 for 36 months, SG$565,262.48
NTU - EDEX Grant: Investigating the Effectiveness of 3D Printed Models in Anatomy Teaching 2015; with Dr Sreenivasulu Reddy Mogali (LKCMedicine) and Asst Prof Yeong Wai Yee (School of Mechanical and Aerospace Engineering) From December 2015 for 1 year; S$35,000
Tier 1 ID:2015-T1-001-083. Structural changes in contracting skeletal and cardiac muscle fibres measured by FRET. 2-years from February 2016; S$175,000
NRF - COMPETITIVE RESEARCH PROGRAMME(CRP) Fiber Medical devices for diagnosis of coronary artery disease; NRF-CRP13-2014-05; Lead PI: Liu Linbo; Co-PI: Shum Ping, Michael Alan Ferenczi, Weihua Song,Philip Wong En Hou, Nicolas Foin, Guillermo J. Tearney; S$ 7,690,000 over 5 years from December 2015.
Singapore Ministry of Education Tier 1, MOE2013-T1-002-186; "The role of titin mutations in modifying the contractile performance of cardiac myofibrils", 01-Mar-2014 for 36 months, SG$394,487.17

Expired grants:

Singapore Ministry of Education Tier 2, MOE2012-T2-2-105; "The molecular basis of the stretch response in skeletal and cardiac muscles", 03-Jun-2013 for 36 months, SG$695,753
Collaboration Development Award - Translational Skin Biology; Foreign and Commonwealth Office Global Partnership Funds, with Xu Chenjie (Asst Prof), Division of Bioengineering, School of Chemical and Biomedical Engineering, NTU. Travel grant to David Teo to investigate SHG microscopy with Dr. Valentina Caorsi at NHLI, Imperial College London; January 2013; S$3,500.00
King Fahd Fund Ph.D. studentship awarded to Sara Abou Al-Saud from December 2011, for 3 years, in collaboration with Professors Ralph Knöll and Steve Marston. £90,000. "Functional Analysis of cardiomyopathy in mouse models and exploration of therapeutic interventions: what is the interaction between Myosin Binding Protein C and Calcineurin?"
BHF: With Professors Steve Marston and Ralph Knöll. Programme Grant WHCH P38848 "Molecular mechanisms by which mutations in myofibrillar proteins cause primary cardiomyopathies". Subproject PS5586 £267,136. January 2012 to December 2016.
BBSRC: Standard Research Grant BB/LO19448 "Novel approaches to elucidate the molecular basis of muscle contraction: FRET-FLIM imaging applied to single muscle fibres". £371,000. August 1, 2011 for 36 months
WT091460MA - Wellcome Trust-NIH studentship awarded to Christopher Töpfer from October 2010, for 4 years, in collaboration with Dr. Jim Sellers, NIH."Investigation of the role of myosin light chain phosphorylation on the stress response of the heart using permeabilised trabeculae and single myosin molecules."
BHF: With Professors Steve Marston, Nancy Curtin, and Nick Wells RG/08/010/25918 Molecular Mechanisms of contractile dysfunction in cardiac muscle hypertrophy and failure £636,991. September 5, 2008 for 36 months
Royal Society: Newton International Fellowship awarded to Dr. Valentina Caorsi. Myosin head movement in contracting muscle fibres detected by Forster Resonance Energy Transfer. £98,000. January 1, 2009 for 24 months
BBSRC: With Professor Paul French and Dr. Mark Neil BB/E021573/1 Muscle cross-bridge mechanism investigated by fluorescence lifetime imaging microscopy of myosin essential light chain £544,441 (indexed FEC). July 1, 2007 for 36 months
MRC Milstein Fund: With Professor Paul French and Dr. Mark Neil G0601747 Strain-sensitivity of muscle fibre cross-bridges investigated by fluorescence life-time imaging microscopy £372,882. February 1, 2007 for 36 months
British Heart Foundation: Applicant: Prof. Steven Marston; Co-applicants: Prof. Dominic Wells, Prof. Sian E. Harding, Prof. M.A. Ferenczi. PG/06/025/20396. Development and functional investigation of transgenic mouse models of dilated and hypertrophic cardiomyopathy. £267,921 01/04/06-31/03/09
MRC: Sole Principal applicant G0501704 The tuning mechanism of the molecular engines in muscle. £815,760 (FEC) 7/01/07-31/12/09
Wellcome Trust GR077190MA: Co-applicant with Prof. R.C. Woledge. Principal applicant: Dr. N.A. Curtin. 'How muscles work: a new look at energy conversion and ATP turnover during filament sliding'. £285,421. August 1, 2006 for 36 months.
BBSRC: Oxford Bionanotechnology IRC - 2003-2007 - £205,022
MRC: Sole Principal applicant G0100150 Towards a molecular understanding of energy transduction in muscle. Programme grant. £821,862 1 December 2001- 30 November 2006.
BBSRC: Principal Investigator: REI20560 Multiuser TIRF microscopy setup for realtime cellular and molecular imaging. £66,796 01/10/2003 - 01/10/2004 (Equipment grant only)
Wellcome Trust: Co-applicant with Prof. R.C. Woledge. Principal applicant Dr. N.A. Curtin. Energy conversion during contraction: a new look at ATP use by muscle fibres. £130,530 over four years, starting November 1999. 10% time. Grant No. 056162
Non-UK sources:
INTAS: Changes in molecular structure underlying muscle contraction €56,000 from 1 October 1998 for 36 months collaborative programme (Dr. A. Tsaturyan, Moscow State University and Dr. S. Bershitsky, Urals branch of Russian Academy of Sciences, Ekaterinburg).
NIH: Joint investigator in grant 'Mechanisms in vascular smooth muscle' with D.R. Trentham, J.E.T. Corrie, M.R. Webb. Principal investigator Professor A.V. Somlyo (NIH Programme Project. This section of the 5-year grant (£42,000 p.a.) is to support a post doctoral worker and consumables in the laboratory of Dr. J.E.T. Corrie at NIMR.
EU: Dr. M.A. Ferenczi, together with Drs. D. R.Trentham, M. Anson, J.E.T. Corrie and M.R. Webb (Overall co-ordinator, M.R. Webb) form part of a research training network involving 11 European laboratories to support 10 post-doctoral positions of 2 to 3 years and workshops. NIMR budget: £38,000 p.a.
NATO: Collaborative Linkage Grant - Ref. 977819. Study of structural basis of muscle contraction with X-ray diffraction on muscle fibres using synchrotron radiation $38,500; 2001-2002; with Drs. Bershitsky and Tsaturyan.

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